PUBLICACIONES
YEAR 2021
YEAR 2020
YEAR 2019
YEAR 2018
YEAR 2017
YEAR 2016
YEAR 2015
YEAR 2014
YEAR 2013
YEAR 2012
YEAR 2011
YEAR 2010
PUBLICATIONS YEAR 2021
Dopamine DR2R is requiered for Hippocampal-dependent Memory and Plasticity at the CA2-CA1 Synapse.
Espadas I, Ortiz O, García-Sanz P, Sanz-Magro A, Alberquilla S., Solis O, Delgado-García JM, Gruart A & Moratalla R.
Cerex Cortex. 2021 Mar 5; 31(4): 2187-2204. doi:10.1093/cercor/bhaa354. PMID:33264389.
Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210.
Serrano A, Vadas E, Ferrer B, Bilbao A, Granado N, Suárez J, Pavon FJ, Moratalla R & Rodríguez de Fonseca F.
Psychopharmacology (Berl). 2021 Feb;238(2):551-557. doi: 10.1007/s00213-020-05704-8. Epub 2021 Jan 7.PMID: 33410990
Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine D1 or dopamine D2 receptors.
Rivera, P., Aranda, J., Alén, F., Vargas, A., Serrano, A., Pavón, F. J., Orio, L., Rubio, L., Moratalla, R., de Fonseca, F. R., & Suárez, J.
The Journal of comparative neurology. 2021. 529(8):1724-1742. doi: 10.1002/cne.25052.
PUBLICATIONS YEAR 2020
The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson’s Disease.
García-Sanz, P., M F G Aerts, J., & Moratalla, R.
Movement disorders. 2020 Nov. doi: org/10.1002/mds.28396.
Dopamine D1 Receptors Regulate Spines in Striatal Direct-Pathway and Indirect-Pathway Neurons.
Suarez, L. M., Solis, O., Sanz-Magro, A., Alberquilla, S., & Moratalla, R.
Movement disorders. 2020 Oct. 35(10):1810-1821. doi: 10.1002/mds.28174.
Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice.
Pérez-Taboada, I., Alberquilla, S., Martín, E. D., Anand, R., Vietti-Michelina, S., Tebeka, N. N., Cantley, J., Cragg, S. J., Moratalla, R., & Vallejo, M.
Movement disorders. 2020 Sep. . 35(9):1636-1648. doi: 10.1002/mds.28124.
Beneficial effects of the phytocannabinoid Δ9-THCV in L-DOPA-induced dyskinesia in Parkinson’s disease.
Espadas, I., Keifman, E., Palomo-Garo, C., Burgaz, S., García, C., Fernández-Ruiz, J., & Moratalla, R.
Neurobiology of disease. 2020 Jul. 141:104892. doi: 10.1016/j.nbd.2020.104892.
DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Barroso-Chinea, P., Luis-Ravelo, D., Fumagallo-Reading, F., Castro-Hernandez, J., Salas-Hernandez, J., Rodriguez-Nuñez, J., Febles-Casquero, A., Cruz-Muros, I., Afonso-Oramas, D., Abreu-Gonzalez, P., Moratalla, R., Millan, M. J., & Gonzalez-Hernandez, T.
Autophagy. 2020 Jul. 16(7):1279-1295. doi: 1080/15548627.2019.1668606.
Modeling Parkinson disease with the alpha-synuclein protein.
Gómez-Benito M, Granado N, García-Sanz P, Michel A, Dumoulin M, and Moratalla R.
Front. Pharmacol. 2020 Apr. 11:356. doi: 10.3389/fphar.2020.00356.
Dopamine regulates spine density in striatal projection neurons in a concentration-dependent manner.
Alberquilla S, Gonzalez-Granillo A, Martín ED, Moratalla R.
Neurobiol. Dis. 2020 Feb. 134:104666. doi: 10.1016/j.nbd.2019.104666.
A collection of three integration-free iPSCs derived from old male and female healthy subjects.
Rodríguez-Traver E, Díaz-Guerra E, Rodríguez C, Arenas F, Orera M, Kulisevsky J, Moratalla R, and Vicario C.
Stem Cell Res. 2020 Jan. 2:101663. doi: 10.1016/j.scr.2019.101663.
PUBLICATIONS YEAR 2019
Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice.
Solís O, García-Sanz P, Martín AB, Granado N, Sanz-Magro A, Podlesniy P, Trullas R, Murer MG, Maldonado R, and Moratalla R.
Addict Biol. 2019 Dec. 12:e12840. doi: 10.1111/adb.12840.
Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure.
Del Río-Martín A, Pérez-Taboada I, Fernández-Pérez A, Moratalla R, de la Villa P, Vallejo M.
Cell Rep. 2019 Dec. 29(11):3678-3692.e4. doi: 10.1016/j.celrep.2019.11.027.
Generation of an integration-free iPSC line, ICCSICi005-A, derived from a Parkinson’s disease patient carrying the L444P mutation in the GBA1 gene.
Rodríguez-Traver E, Rodríguez C, Díaz-Guerra E, Arenas F, Araúzo-Bravo M, Orera M, Kulisevsky J, Moratalla R, Vicario C.
Stem Cell Res. 2019 Oct. 40:101578. doi: 10.1016/j.scr.2019.101578.
DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Barroso-Chinea P, Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Salas-Hernandez J, Rodriguez-Nuñez J, Febles-Casquero A, Cruz-Muros I, Afonso-Oramas D, Abreu-Gonzalez P, Moratalla R, Millan MJ, Gonzalez-Hernandez T.
Autophagy. 2019 Oct. 2:1-17. doi: 10.1080/15548627.2019.1668606.
Changes in Dendritic Spine Density and Inhibitory Perisomatic Connectivity onto Medium Spiny Neurons in L-Dopa-Induced Dyskinesia.
Gomez G, Escande MV, Suarez LM, Rela L, Belforte JE, Moratalla R, Murer MG, Gershanik OS, Taravini IRE.
Mol Neurobiol. 2019 Sep. 56(9):6261-6275. doi: 10.1007/s12035-019-1515-4.
A collection of integration-free iPSCs derived from Parkinson’s disease patients carrying mutations in the GBA1 gene.
Rodríguez-Traver E, Díaz-Guerra E, Rodríguez C, Fernández P, Arenas F, Araúzo-Bravo M, Orera M, Kulisevsky J, Moratalla R, Vicario C.
Stem Cell Res. 2019 Jul. 38:101482. doi: 10.1016/j.scr.2019.101482.
Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L-DOPA in a mouse model of Parkinson’s disease.
Keifman E, Ruiz-DeDiego I, Pafundo DE, Paz RM, Solís O, Murer MG, Moratalla R.
Br J Pharmacol. 2019 Jul. 176(13):2146-2161. doi: 10.1111/bph.14663.
Genetic Knockdown of mGluR5 in Striatal D1R-Containing Neurons Attenuates L-DOPA-Induced Dyskinesia in Aphakia Mice.
García-Montes JR, Solís O, Enríquez-Traba J, Ruiz-DeDiego I, Drucker-Colín R, Moratalla R.
Mol Neurobiol. 2019 Jun. 56(6):4037-4050. doi: 10.1007/s12035-018-1356-6.
PUBLICATIONS YEAR 2018
Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin.
Ruiz-DeDiego I, Fasano S, Solís O, Garcia-Montes JR, Brea J, Loza MI, Brambilla R, Moratalla R.
Sci Rep. 2018 Oct. 8(1):15381. doi: 10.1038/s41598-018-33713-3.
Striatal Reinnervation Process after Acute Methamphetamine-Induced Dopaminergic Degeneration in Mice.
Granado N, Ares-Santos S, Tizabi Y, Moratalla R.
Neurotox Res. 2018 Oct. 34(3):627-639. doi: 10.1007/s12640-018-9925-z.
Dopamine receptors: homomeric and heteromeric complexes in L-DOPA-induced dyskinesia.
Solís O, Moratalla R.
J Neural Transm (Vienna). 2018 Aug. 125(8):1187-1194. doi: 10.1007/s00702-018-1852-x.
Differential Synaptic Remodeling by Dopamine in Direct and Indirect Striatal Projection Neurons in Pitx3-/- Mice, a Genetic Model of Parkinson’s Disease.
Suarez LM, Alberquilla S, García-Montes JR, Moratalla R.
J Neurosci. 2018 Apr.38(15):3619-3630. doi: 10.1523/JNEUROSCI.3184-17.2018.
Cholesterol and multilamellar bodies: Lysosomal dysfunction in GBA-Parkinson disease.
García-Sanz P, Orgaz L, Fuentes JM, Vicario C, Moratalla R.
Autophagy. 2018. 14(4):717-718. doi: 10.1080/15548627.2018.1427396.
The importance of cholesterol in Parkinson’s disease.
García-Sanz P and Moratalla R.
Mov Disord. 2018 Feb. 33(2):343-344. doi: 10.1002/mds.27251.
PUBLICATIONS YEAR 2017
N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson’s disease.
García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, Kulisevsky J, Gutierrez A, Dávila JC, González-Polo RA, Fuentes JM, Mir P, Vicario C, Moratalla R.
Mov Disord. 2017 Oct;32(10):1409-1422. doi: 10.1002/mds.27119.
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
Moratalla R, Khairnar A, Simola N, Granado N, García-Montes JR, Porceddu PF, Tizabi Y, Costa G, Morelli M.
Prog Neurobiol. 2017 Aug;155:149-170. doi: 10.1016/j.pneurobio.2015.09.011.
Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice.
Solís O, García-Montes JR, Garcia-Sanz P, Herranz AS, Asensio MJ, Kang G, Hiroi N, Moratalla R.
Neurobiol Dis. 2017 Jun. 102:133-139. doi: 10.1016/j.nbd.2017.03.006.
Dopamine D3 Receptor Modulates l-DOPA-Induced Dyskinesia by Targeting D1 Receptor-Mediated Striatal Signaling.
Solís O, Garcia-Montes JR, González-Granillo A, Xu M, Moratalla R.
Cereb Cortex. 2017 Jan. 27(1):435-446. doi: 10.1093/cercor/bhv231.
Striatal activation by optogenetics induces dyskinesias in the 6-hydroxydopamine rat model of Parkinson disease.
F Hernández L, Castela I, Ruiz-DeDiego I, Obeso JA, Moratalla R.
Mov Disord. 2017 Apr. 32(4):530-537. doi: 10.1002/mds.26947.
Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy.
García-Sanz P, Mirasierra M, Moratalla R, Vallejo M.
Sci Rep. 2017 Mar. 7(1):389. doi: 10.1038/s41598-017-00334-1.
PUBLICATIONS YEAR 2016
L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia.
Suarez LM, Solís O, Aguado C, Lujan R, Moratalla R.
Cereb Cortex. 2016 Oct. 26(11):4253-4264. doi: 10.1093/cercor/bhw263.
Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice.
Mendieta L, Granado N, Aguilera J, Tizabi Y, Moratalla R.
Int J Neuropsychopharmacol. 2016 Aug. 19(8). doi: 10.1093/ijnp/pyw021.
L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum.
Solís O, García-Sanz P, Herranz AS, Asensio MJ, Moratalla R.
Neurotox Res. 2016 Jul. 30(1):67-75. doi: 10.1007/s12640-016-9612-x.
Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells.
Rodríguez-Traver E, Solís O, Díaz-Guerra E, Ortiz Ó, Vergaño-Vera E, Méndez-Gómez HR, García-Sanz P, Moratalla R, Vicario-Abejón C.
Neurotox Res. 2016 Jul;30(1):14-31. doi: 10.1007/s12640-015-9586-0.
PUBLICATIONS YEAR 2015
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways.
Martín R, Bajo-Grañeras R, Moratalla R, Perea G, Araque A.
Science. 2015 Aug. 349(6249):730-4. doi: 10.1126/science.aaa7945.
Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes.
Vergaño-Vera E, Díaz-Guerra E, Rodríguez-Traver E, Méndez-Gómez HR, Solís Ó, Pignatelli J, Pickel J, Lee SH, Moratalla R, Vicario-Abejón C.
Dev Neurobiol. 2015 Aug. 75(8):823-41. doi: 10.1002/dneu.22251.
Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.
Ruiz-DeDiego I, Naranjo JR, Hervé D, Moratalla R.
Mov Disord. 2015 Jul. 30(8):1039-49. doi: 10.1002/mds.26197.
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
Solís O, Espadas I, Del-Bel EA, Moratalla R.
Neurobiol Dis. 2015 Jan. 73:49-59. doi: 10.1016/j.nbd.2014.09.010.
Activation of DREAM (downstream regulatory element antagonistic modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice.
Ruiz-DeDiego I, Mellstrom B, Vallejo M, Naranjo JR, Moratalla R.
Biol Psychiatry. 2015 Jan 15.77(2):95-105. doi: 10.1016/j.biopsych.2014.03.023.
Methamphetamine-induced toxicity in indusium griseum of mice is associated with astro- and microgliosis.
Carmena A, Granado N, Ares-Santos S, Alberquilla S, Tizabi Y, Moratalla R.
Neurotox Res. 2015 Apr. 27(3):209-16. doi: 10.1007/s12640-014-9505-9.
Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake.
Castro-Hernández J, Afonso-Oramas D, Cruz-Muros I, Salas-Hernández J, Barroso-Chinea P, Moratalla R, Millan MJ, González-Hernández T.
Neurobiol Dis. 2015 Feb.74:325-35. doi: 10.1016/j.nbd.2014.12.007.
PUBLICATIONS YEAR 2014
Dyskinesia in Parkinson’s disease: mechanisms and current non-pharmacological interventions.
Heumann R, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Colín R, Garcia-Montes JR, Simola N, Morelli M.
J Neurochem. 2014 Aug;130(4):472-89. doi: 10.1111/jnc.12751.
Aging-related dysregulation of dopamine and angiotensin receptor interaction.
Villar-Cheda B, Dominguez-Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira-Garcia JL.
Neurobiol Aging. 2014 Jul. 35(7):1726-38. doi: 10.1016/j.neurobiolaging.2014.01.017.
D1 but not D4 dopamine receptors are critical for MDMA-induced neurotoxicity in mice.
Granado N, Ares-Santos S, Moratalla R.
Neurotox Res. 2014 Jan;25(1):100-9. doi: 10.1007/s12640-013-9438-8.
L-DOPA treatment selectively restores spine density in dopamine receptor D2-expressing projection neurons in dyskinetic mice.
Suárez LM, Solís O, Caramés JM, Taravini IR, Solís JM, Murer MG, Moratalla R.
Biol Psychiatry. 2014 May. 75(9):711-22. doi: 10.1016/j.biopsych.2013.05.006.
Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining.
Ares-Santos S, Granado N, Espadas I, Martinez-Murillo R, Moratalla R.
Neuropsychopharmacology. 2014 Apr. 39(5):1066-80. doi: 10.1038/npp.2013.307.
Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a mouse model of Parkinson´s disease.
González-Aparicio R, Moratalla R.
Neurobiol Dis. 2014 Feb;62:416-25. doi: 10.1016/j.nbd.2013.10.008.
The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum.
Urrutia A, Granado N, Gutierrez-Lopez MD, Moratalla R, O’Shea E, Colado MI.
Int J Neuropsychopharmacol. 2014 Feb. 17(2):235-46. doi: 10.1017/S1461145713000850.
PUBLICATIONS YEAR 2013
Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.
Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF.
PLoS One. 2013 Nov 28. 8(11):e80902. doi: 10.1371/journal.pone.0080902.
Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders.
Peraile I, Granado N, Torres E, Gutiérrez-López MD, Moratalla R, Colado MI, O’Shea E.
Psychopharmacology (Berl). 2013 Nov;230(1):125-35. doi: 10.1007/s00213-013-3142-5.
A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.
López-Jiménez A, Walter NA, Giné E, Santos Á, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA.
Synapse. 2013 Jun;67(6):280-9. doi: 10.1002/syn.21639.
The role of dopamine receptors in the neurotoxicity of methamphetamine.
Ares-Santos S, Granado N, Moratalla R.
J Intern Med. 2013 May;273(5):437-53. doi: 10.1111/joim.12049.
Methamphetamine and Parkinson’s disease.
Granado N, Ares-Santos S, Moratalla R.
Parkinsons Dis. 2013. 2013:308052. doi: 10.1155/2013/308052.
PUBLICATIONS YEAR 2012
L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: insights into regulation and function.
Espadas I, Darmopil S, Vergaño-Vera E, Ortiz O, Oliva I, Vicario-Abejón C, Martín ED, Moratalla R.
Neurobiol Dis. 2012 Dec. 48(3):271-81. doi: 10.1016/j.nbd.2012.07.012.
New strategies in neuroprotection and neurorepair.
Antonelli MC, Guillemin GJ, Raisman-Vozari R, Del-Bel EA, Aschner M, Collins MA, Tizabi Y, Moratalla R, West AK.
Neurotox Res. 2012 Jan. 21(1):49-56. doi: 10.1007/s12640-011-9265-8.
Involvement of cannabinoid CB1 receptor in associative learning and in hippocampal CA3-CA1 synaptic plasticity.
Madroñal N, Gruart A, Valverde O, Espadas I, Moratalla R, Delgado-García JM.
Cereb Cortex. 2012 Mar. 22(3):550-66. doi: 10.1093/cercor/bhr103.
Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine.
Ares-Santos S, Granado N, Oliva I, O’Shea E, Martin ED, Colado MI, Moratalla R.
Neurobiol Dis. 2012 Feb;45(2):810-20. doi: 10.1016/j.nbd.2011.11.005.
Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons.
Busceti CL, Bucci D, Molinaro G, Di Pietro P, Zangrandi L, Gradini R, Moratalla R, Battaglia G, Bruno V, Nicoletti F, Fornai F.
PLoS One. 2012. 7(9):e44025. doi: 10.1371/journal.pone.0044025.
PUBLICATIONS YEAR 2011
Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum.
Granado N, Lastres-Becker I, Ares-Santos S, Oliva I, Martin E, Cuadrado A, Moratalla R.
Glia. 2011 Dec. 59(12):1850-63. doi: 10.1002/glia.21229.
Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain.
Suárez J, Ortíz O, Puente N, Bermúdez-Silva FJ, Blanco E, Fernández-Llebrez P, Grandes P, de Fonseca FR, Moratalla R.
Neuroscience. 2011 Sep. 192:112-31. doi: 10.1016/j.neuroscience.2011.06.062.
Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long-Term Memory Involving D1 Dopamine Receptor Stimulation.
Murer MG, Moratalla R.
Front Neuroanat. 2011 Aug. 11;5:51. doi: 10.3389/fnana.2011.00051.
Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA.
Granado N, Ares-Santos S, Oliva I, O’Shea E, Martin ED, Colado MI, Moratalla R.
Neurobiol Dis. 2011 Jun. 42(3):391-403. doi: 10.1016/j.nbd.2011.01.033.
The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate.
Méndez-Gómez HR, Vergaño-Vera E, Abad JL, Bulfone A, Moratalla R, de Pablo F, Vicario-Abejón C.
Mol Cell Neurosci. 2011 Jan. 46(1):108-21. doi: 10.1016/j.mcn.2010.08.011.
Induction of c-Fos in ‘panic/defence’-related brain circuits following brief hypercarbic gas exposure.
Johnson PL, Fitz SD, Hollis JH, Moratalla R, Lightman SL, Shekhar A, Lowry CA.
J Psychopharmacol. 2011 Jan. 25(1):26-36. doi: 10.1177/0269881109353464.
Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.
Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R.
J Biol Chem. 2011 Feb. 286(7):5846-54. doi: 10.1074/jbc.M110.161489.
PUBLICATIONS YEAR 2010
Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice.
Ortiz O, Delgado-García JM, Espadas I, Bahí A, Trullas R, Dreyer JL, Gruart A, Moratalla R.
J Neurosci. 2010 Sep. 30(37):12288-300. doi: 10.1523/JNEUROSCI.2655-10.2010.
Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum.
Gramage E, Rossi L, Granado N, Moratalla R, Herradón G.
Neuroscience. 2010 Sep 29. 170(1):308-16. doi: 10.1016/j.neuroscience.2010.06.078.
Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors.
Ramiro-Fuentes S, Ortiz O, Moratalla R, Fernandez-Espejo E.
Neuroscience. 2010 May 5;167(2):205-15. doi: 10.1016/j.neuroscience.2010.02.019.
Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine.
Granado N, Ares-Santos S, O’Shea E, Vicario-Abejón C, Colado MI, Moratalla R.
Neurotox Res. 2010 Jul;18(1):48-58. doi: 10.1007/s12640-009-9106-1.